Why is benzyl alcohol contraindicated in neonates?

90 mg/kg/day Must not be given to premature babies or neonates. Due to the risk of fatal toxic reactions arising from exposure to benzyl alcohol in excess of 90 mg/kg/day, this product should not be used in infants and children up to 3 years old.

What preservatives are toxic to neonates?

Among excipients known to be harmful for neonates, ethanol, propylene glycol, saccharin sodium and benzoates were present in at least two pharmaceutical preparations of antibiotics (intravenous formulations), iron, vitamins and antifungals (oral formulations) [1].

Why is benzyl alcohol harmful?

Side Effects of Benzyl Alcohol

Can cause itching for some people: “As is the case for most preservatives, benzyl alcohol can, unfortunately, be an irritant and cause itching for some people,” says Krant.

Is benzyl alcohol safe during pregnancy?

Benzyl alcohol topical is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether benzyl alcohol topical passes into breast milk. However, this medicine contains a preservative that may be harmful to a newborn.

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Is benzyl alcohol safe for breastfeeding?

Benzyl alcohol and Lactation

It is not known if benzyl alcohol passes into your breast milk or if it can harm your baby. You should choose to breastfeed or use benzyl alcohol, but not both. Talk to your healthcare provider about other ways to feed your baby while using benzyl alcohol.

How is benzyl alcohol metabolized?

Benzyl Alcohol is an aromatic alcohol used in a wide variety of cosmetic formulations as a fragrance component, preservative, solvent, and viscosity-decreasing agent. Benzyl alcohol is metabolized to Benzoic Acid, which reacts with glycine and excreted as hippuric acid in the human body.

What is GREY syndrome?

The gray baby syndrome is a type of circulatory collapse that can occur in premature and newborn infants and is associated with excessively high serum levels of chloramphenicol. 425. It is characterized by an ashen-gray color, abdominal distention, vomiting, flaccidity, cyanosis, circulatory collapse, and death.

Why is bacteriostatic water not for neonates?

Dosage for Bacteriostatic Water

It is not used for neonatal medications because of possible blood pressure changes and toxicity of benzyl alcohol. If Bacteriostatic Water is injected intravenously without any diluted compound, it may cause some red blood cell lysis because it is not isotonic.

What is the purpose of benzyl alcohol?

Benzyl alcohol lotion is used to treat head lice (small insects that attach themselves to the skin) in adults and children 6 months of age and older. It should not be used in children less than 6 months of age. Benzyl alcohol is in a class of medications called pediculicides. It works by killing the lice.

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Does benzyl alcohol contain alcohol?

Benzyl alcohol is fragrance and flavor material that also has preservative qualities. … Although the term “alcohol” is used in the name, it does not contain any ethanol, the volatile alcohol found in alcoholic beverages and mouthwash products, and may be present in products that are considered alcohol free.

Can baby use benzyl benzoate?

Adults—Use just one time. For severe cases, treatment may be repeated after twenty-four hours one time anytime within five days. For infants: Use mixed with three parts of water, just one time. For older children: Use mixed with an equal quantity of water, just one time.

Does benzyl alcohol cross the placenta?

Because benzyl alcohol may cross the placenta, however, the package insert of benzyl alcohol–containing vials contains the warning that it should not be used during pregnancy.

Is benzyl benzoate the same as benzyl alcohol?

Benzyl benzoate is a benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia. It has a role as a scabicide, an acaricide and a plant metabolite. It is a benzyl ester and a benzoate ester.

How do you use benzyl benzoate on babies?

For lice infestation:

  1. Adults—Use just one time. For severe cases, treatment may be repeated two or three times after twenty-four hours.
  2. Children— For infants: Use mixed with three parts of water, just one time. For older children: Use mixed with an equal quantity of water, just one time.

Is Benzyl salicylate safe during pregnancy?

Both of these body products have a detoxifying effect on the body and detoxification is not recommended for pregnant mothers as it can cause dehydration and may increase the toxic load in the mother’s blood, which will also pass through to the baby.

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What is phenoxyethanol in skin care?

Phenoxyethanol is an ingredient in cosmetic products that serves as a preservative. In soaps and perfumes, it is used as a stabilizer.